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THE EFFECT OF THE INTRAVENOUS INJECTION OF HEPARIN ON THE INTERACTION OF CHYLE AND PLASMA IN THE RAT
Author(s) -
French J. E.,
Robinson D. S.,
Florey H. W.
Publication year - 1953
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1953.sp001008
Subject(s) - clearance , heparin , chyle , chemistry , chromatography , metabolic clearance rate , medicine , biochemistry , pharmacokinetics , urology , complication
1. When chyle is added in vitro to the plasma of rats which have received an intravenous injection of heparin, there is a progressive fall in turbidity. 2. The rate of clearing depends on the concentration in the plasma of a factor which is formed following the injection of heparin. The concentration of this factor depends in turn on the amount of heparin injected, but the relationship between the two is not linear. 3. The amount of chyle cleared is independent of the amount of heparin injected over the range 5 to 500 units heparin per kg. of body weight. It does depend on a second factor which is present in normal as well as in heparinised plasma. 4. When chyle is added in excess to plasma containing the heparin factor, the particulate lipid which is not cleared shows changed properties and can then be cleared by normal plasma.