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THE NORMAL INTERPHASE IN THE POLYURIA WHICH FOLLOWS SECTION OF THE SUPRAOPTICO‐HYPOPHYSIAL TRACTS IN THE DOG
Author(s) -
O'Connor W. J.
Publication year - 1952
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1952.sp000976
Subject(s) - polyuria , antidiuretic , diuresis , endocrinology , urine osmolality , medicine , urine , sodium , posterior pituitary , pituitary gland , chemistry , kidney , vasopressin , hormone , organic chemistry , diabetes mellitus
1. Four facts have been established concerning the period from the 6th to 11th days following section of the supraoptico‐hypophysial tracts in the dog: ( a ) The daily urine volume is low (the “normal interphase” of Fisher, Ingram and Ranson [1938] between the temporary and permanent polyurias). ( b ) There is no diuretic response to administered water. Neither ( a ) nor ( b ) occurs following operative removal of the posterior lobe of the pituitary. ( c ) Sodium chloride administered by stomach tube in isotonic solution is excreted freely but in a small volume of urine of high chloride concentration. ( d ) Antidiuretic activity is present in the urine. 2. These facts indicate, and are adequately explained by, the conclusion that during the 6th‐llth days after section of the tracts active material escapes from the degenerating pars nervosa of the pituitary into the blood stream at rates up to 0·3 mU per min.