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OBSERVATIONS ON THE URINARY EXCRETION OF HISTAMINE IN URTICARIA
Author(s) -
Adam H. M.,
Hunter R. B.,
Kinnear T. W. G.
Publication year - 1950
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1950.sp000960
Subject(s) - histamine , excretion , urinary system , medicine , vein , endocrinology , anesthesia
1. The effect on the urinary histamine of histamine given by mouth or by intravenous infusion was studied in three men with chronic urticaria and found not to differ from that recorded in normal men. Two of these men who received histamine intravenously developed some hours later an urticarial reaction of unusual severity. 2. In two of the intravenous infusions no changes were detected in the histamine content of the plasma or cells obtained from the antecubital vein; no changes were detected in a single sample withdrawn from the femoral artery. The possible significance of this result is discussed. 3. The mean daily excretion of free histamine in a group of nine cases of urticaria differed significantly from the mean in a group of ten patients with other diseases and in a group of ten normal and convalescent subjects. The mean daily excretion of conjugated histamine did not differ significantly in the three groups. These results support the conception that histamine is either liberated or newly formed in urticaria.