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SOME OBSERVATIONS ON THE BRONCHOCONSTRICTOR EFFECTS OF TUBOCURARINE
Author(s) -
Maefouz M.
Publication year - 1949
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1949.sp000949
Subject(s) - bronchoconstriction , d tubocurarine , histamine , constriction , guinea pig , anesthesia , medicine , pharmacology , airway
A rapid intravenous injection of tubocurarine usually causes broncho‐constriction in guinea‐pigs. A second injection has no such effect. The effect may be prevented or interrupted by neoantergan, and is probably due to the release of histamine. The best way to avoid this effect in the clinical use of tubocurarine is to give the injection slowly. Slow injections of large doses in guinea‐pigs had no effect on the bronchi, although a dose 10–15 times smaller caused bronchoconstriction when given rapidly.