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DETERMINATION OF BLOOD VOLUME IN DOG BY MEANS OF VISUALLY LABELLED ERYTHROCYTES
Author(s) -
Nizet A.
Publication year - 1948
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1948.sp000919
Subject(s) - phenylhydrazine , volume (thermodynamics) , blood volume , body weight , chemistry , chromatography , biology , medicine , endocrinology , thermodynamics , physics , organic chemistry
A new technique is described for the measurement of circulating blood volume, using visually labelled erythrocytes. These elements are prepared by the action in vitro of phenylhydrazine on the erythrocytes. The granular elements remain in the circulating blood long enough to allow good mixing. Successive determinations in the same animal show good agreement. The average circulating blood volume of the normal dog is found to be 66 c.c. per kg. body‐weight.