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THE RELATIONSHIP OF THE THYROID GLAND TO MUSCULAR WORK PERFORMED BY THE ALBINO RAT
Author(s) -
Cox L. W.
Publication year - 1948
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1948.sp000918
Subject(s) - thyroid , endocrinology , medicine , thyroidectomy , hormone , muscular fatigue , physical therapy
1. Muscular work performed by the sciatic nerve‐gastrocnemius muscle preparation in the anæthetised rat is recorded when normal, high, and low thyroid hormone levels are present. 2. Hypothyroid animals performed less work than normal animals. 3. Hyperthyroid animals performed less work than normal animals. 4. Thyroidectomized animals, with iodine added to the diet, performed work at a rate not significantly different from normal animals. 5. All animals on which thyroidectomy had been performed, showed a phase of sustained contraction, lasting ¼ to 2 hours, at the commencement of the experiment. This phase was not due to hypocalcæmia, and possibly was not due to defective neuro‐muscular transmission. 6. No animal, normal or abnormal in thyroid metabolism under the conditions stated, showed muscular fatigue during the twenty hours of the experiment.