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“AVIDITY” OF ANTI‐A AGGLUTINATING SERA
Author(s) -
Barnes D. W. H.,
Loutit J. F.
Publication year - 1947
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1947.sp000916
Subject(s) - agglutination (biology) , avidity , immunology , immune system , antibody , immune sera , biology , chemistry
“Avidity” of anti‐A blood‐grouping sera was measured by ( a ) the unagglutinated red cell count, ( b ) the time of agglutination, with A 1 and A 2 red cells. With each serum agglutination time was always shortest with the lowest dilution. The lowest unagglutinated cell count was with A 2 cell usually in the lowest serum dilution, but with A 1 cells was variable. Agglutination time and agglutinating strength are therefore probably determined by different factors in serum. Immune rabbit sera approximated to the ideal anti‐A blood‐grouping sera rather than natural or immune human sera. We should like to thank Dr. W. T. J. Morgan of the Lister Institute for his help and for liberal supplies of immnlune rabbit sera.