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ON THE METABOLISM OF HISTAMINE
Author(s) -
Alexander Frank
Publication year - 1944
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1944.sp000897
Subject(s) - histamine , clearance , excretion , endocrinology , kidney , medicine , metabolism , chemistry , pharmacology , urology
The skin of the mice was found to contain more than 60 per cent. of all the histamine in the body. A large dose of histamine was cleared partly by excretion and partly by some other mechanism. Excretion occurred through the kidney, and only whilst a high concentration was present in the body. The whole of a large dose was removed within twenty‐four hours of administration.