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METABOLISM OF LIVER SLICES AFTER BURNING
Author(s) -
Clark E. J.,
Rossiter R. J.
Publication year - 1944
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1944.sp000889
Subject(s) - metabolism , chemistry , biochemistry
1. Anæsthetised rabbits burnt at 70°C. for ½ minute (area of burn ⅓ body surface) show a rise in red blood cell count within 2‐4 hours, which has fallen to normal by 24 hours. 2. There is no change in the ability of the liver to oxidise alanine or sodium butyrate either 4 or 24 hours after burning; there is also no change in the Q G O2 and Qo 2 measured in bicarbonate buffer. 3. After 4 hours there is a fall in the R. Q. (measured in phosphate buffer), rise in the Q G N2 , and fall in the ability of the liver to form glycogen from glucose; these have all returned to normal within 24 hours. 4. After 24 hours there is a slight rise in the Qo 2 measured in phosphate buffer, which is not observed after 4 hours. 5. Implications of these results are discussed and it is concluded that they are in all probability secondary to the circulatory changes following the burn. Thanks are due to Dr. J. M. Barnes for advice and information on the method of burning the animals, and to Miss J. Jenkins for valuable technical assistance. One of us (E. J. C.) is indebted to the Medical Research Council for a personal grant and one (R. J. R.) to the Carnegie Trustees. The Medical Research Council has also contributed to the cost of this Research, which was carried out on behalf of the Burns Sub‐committee of the War Wounds Committee.