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FURTHER OBSERVATIONS ON THE INTERMEDIATE LOBE PITUITARY HORMONE
Author(s) -
Landgrebe F. W.,
Reid E.,
Waring H.
Publication year - 1943
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1943.sp000880
Subject(s) - hormone , chemistry , endocrinology , medicine , urine , insulin , epinephrine , biology
1. Modifications of the Landgrebe‐Waring [1941] method for obtaining a high yield of potent melanophore expanding hormone (“B”) are described. 2. The best product L. R. W. 1 contains per mg.— 85,000 L. W. units “B” 1 Int. Unit pressor. 3. Properties of our new extracts are compared with those of Stehle's [1936] extract. 4. Extracts may be rich in “B” and yet exert no hyperglycæmic or anti‐insulin effects. 5. The hyperglycæmia evoked by 0·1 mg. adrenaline is largely inhibited by subcutaneous injection of 0·25 mg. L. R. W. 1 . It is not claimed that this inhibition is due to “B” hormone itself. 6. No significant amounts of “B” were detected in the blood or urine of untreated rabbits. 7. Aqueous extracts of normal rabbit liver contain a melanophore excitant that, with the tests at present available, is indistinguishable from pituitary “B”‐hormone.