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THE EFFECT OF ASCORBIC ACID (VITAMIN C), CALCIUM ASCORBATE, AND CALCIUM GLUCONATE ON THE REGENERATION OF BONE IN RATS
Author(s) -
Bourne Geoffrey,
MacKin MacKenzie
Publication year - 1942
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1942.sp000865
Subject(s) - ascorbic acid , calcium , vitamin c , chemistry , vitamin , endocrinology , vitamin d and neurology , medicine , biochemistry , food science , organic chemistry
A new technique has been described for the estimation of the power of a substance to accelerate the healing of bone. It has been found by this method that neither vitamin C nor calcium glucono‐galacto‐gluconate in the doses given accelerates the healing of bone in rats on an adequate diet when injected subcutaneously. On the other hand, it has been found that calcium ascorbate injected subcutaneously into rats does statistically increase the amount of bone regenerated by the end of 7 days. The vitamin C used for these experiments was Redoxon, Roche, and I am greatly indebted to Roche Products Ltd., not only for the vitamin C, but also for making the calcium ascorbate specially for this work at my request.