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ADRENAL AND OTHER FACTORS AFFECTING EXPERIMENTAL TRAUMATIC SHOCK IN THE RAT
Author(s) -
Noble R. L.,
Collip J. B.
Publication year - 1942
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1942.sp000857
Subject(s) - traumatic shock , shock (circulatory) , endocrinology , medicine , anesthesia , chemistry
Rats have been subjected to traumatic shock using the method previously described. It has been found that adrenalectomized rats are much more susceptible than normals to this type of trauma. Suitable pretreatment with cortical extract restored their resistance to slightly above normal, and desoxycorticosterone acetate had a less, but definite, beneficial action. The same method of pretreatment was used on normal rats. In this case cortin and desoxycorticosterone caused a slight increase in resistance. Corticotrophic extracts of the pituitary were also effective to about the same extent. From a practical viewpoint the effects of adrenal preparations on this type of shock have been disappointing. The changes in blood concentration following trauma have been recorded and the effects of hæmorrhage and ether anæsthesia have been determined. These results are discussed in relation to the possible factors concerned in the ætiology of shock. This research was assisted by a grant from the National Research Council, Ottawa. We wish to thank Mrs. A. Nielsen and Mr. Larsen for their technical assistance in this experimental work.