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THE INFLUENCE OF SODIUM EVIPAN ON THE HEART AND CIRCULATION
Author(s) -
Das S. C.
Publication year - 1941
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1941.sp000850
Subject(s) - blood pressure , vasodilation , vasomotor , perfusion , circulatory system , medicine , depression (economics) , anesthesia , cardiac output , sodium , cardiology , chemistry , organic chemistry , economics , macroeconomics
1. Intravenous injection of sodium evipan always causes a fall of blood‐pressure. This fall is not due to the reaction of the solution, but is partly due to vasodilation and partly to cardiac depression. 2. Perfusion of cat's leg in situ gives evidence of direct vasodilatation as well as of vasomotor depression. 3. Auricle strip of frog shows 10 per cent. depression with 1 in 50,000 of evipan, 25 per cent. with 1 in 20,000, 40 per cent. with 1 in 10,000, 60 per cent. with 1 in 5000, and 95 to 100 per cent. with 1 in 2000 concentration. 4. Myocardiographic record of cat's heart in situ indicates auricular and ventricular depression even with small doses of evipan, showing that the cardiac factor plays a definite part in causing a fall of blood‐pressure. 5. This depressant effect on circulatory system can be minimised to a great extent by giving the dose in fractions at short intervals, and still better by continuous intravenous infusion. The author gratefully acknowledges his indebtedness to Professor A. J. Clark for his advice and help throughout the course of his work.