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THE INFLUENCE OF CORAMINE ON CIRCULATORY CAROTID SINUS REFLEXES
Author(s) -
Müller Reinhard
Publication year - 1940
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1940.sp000833
Subject(s) - carotid sinus , reflex , circulatory system , blood pressure , medicine , cardiology , peripheral , anesthesia , sinus (botany) , anatomy , biology , botany , genus
1. The blood‐pressure‐decreasing carotid sinus pressure reflex is weakened in urethanised rabbits under the influence of Coramine. An essential increase in the so‐called residual blood‐pressure is to be regarded as a sign of the increase in tone of the peripheral circulation. 2. Both in the urethanised rabbit and in the urethanised cat the blood‐pressure‐raising carotid occlusion reflex shows a larger rise in blood‐pressure under the effect of Coramine than before its administration. This is also to be regarded as a sign of the peripheral vascular tonic effect. This result is obtained both with intact and severed aortic nerves. 3. Coramine produces in animals whose aortic nerve has been severed a larger rise in blood‐pressure than in the intact animal. 4. The effect of Coramine on the carotid sinus itself can be excluded for the results reported. Coramine is capable only in high concentration of influencing the presso‐receptors locally.