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THE SITE OF ACTION OF THYROXIN ON WATER‐METABOLISM
Author(s) -
Brull Lucien
Publication year - 1940
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1940.sp000831
Subject(s) - hypophysectomy , diuretic , endocrinology , medicine , kidney , saline , secretion , water metabolism , action (physics) , site of action , metabolism , chemistry , biology , hormone , physics , quantum mechanics
1. Kidneys originating from thyroxinised dogs, when transplanted simultaneously with control kidneys to a donor anæsthetised with chloralosane, have been found to secrete more rapidly and to give larger responses to saline infusion and to hypophysectomy than the controls. 2. The method adopted and the results obtained demonstrate that the diuretic effect of thyroxin is due, at least in part, to a direct action on the kidney.