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DYNAMIC VARIATION IN RESPONSE TO BARBITURATES
Author(s) -
Clark A. J.,
Raventós J.
Publication year - 1940
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1940.sp000830
Subject(s) - sensitivity (control systems) , duration (music) , variation (astronomy) , psychology , engineering , physics , electronic engineering , astrophysics , acoustics
1. There is a fairly high individual constancy as regards sensitivity to barbiturates; individuals which are narcosised by a median hypnotic dose are likely to show the same response when the test is repeated. 2. There is less individual constancy as regards the duration of narcosis produced by barbiturates. Such constancy can be demonstrated in groups of mice selected as regards sensitivity, but in unselected groups we could not demonstrate any constancy. The expenses of this research were defrayed by a grant from Messrs. Imperial Chemical Industries (Dyestuffs Group), for which the authors express their thanks. We also thank Dr. W. O. Kermack for his kind assistance in the mathematical analysis of the results.