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OBSERVATIONS RELATING TO CARDIAC HYPERTROPHY IN THE RABBIT: ITS PRODUCTION BY ARTERIO‐VENOUS ANASTOMOSIS
Author(s) -
Drury Alan N.,
Wightman K. J. R.
Publication year - 1940
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1940.sp000821
Subject(s) - anastomosis , muscle hypertrophy , medicine , cardiology , ventricle , anatomy , venous valves , external jugular vein , inferior vena cava , vein , surgery
The anastomosis of the right carotid artery into the external jugular vein leads within a short time to cardiac hypertrophy and dilatation. In the auricles the hypertrophy is considerable, the weights being on occasions four times that of the normal auricle. Both auricles share equally in the hypertrophy. In the ventricles the hypertrophy is not so great, the weights seldom being greater than twice the normal. The right ventricle shows a slightly greater hypertrophy than the left. The change of pressure in the right auricle upon closing the anastomosis indicates that the input into the heart is increased. When the anastomosis is closed, the venous pressure in the veins leading to the superior vena cava falls, but rises in those leading to the inferior vena cava. I wish to express my thanks to Dr. T. D. Day and Miss G. Plaut for their help in the histological study of the hearts.