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AN EXPERIMENTAL ANALYSIS OF THE ACTION OF ADRENALINE AND HISTAMINE ON DIFFERENT PARTS OF THE PULMONARY VASCULAR BED
Author(s) -
Daly I. de Burgh,
Foggie P.,
Hebb Catherine O.
Publication year - 1940
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1940.sp000820
Subject(s) - histamine , pulmonary artery , outflow , medicine , pulmonary arterial pressure , anesthesia , venous blood , lung , cardiology , physics , meteorology
In isolated dog's lungs under negative pressure ventilation and perfused at constant volume inflow with defibrinated blood— 1. The increase in pulmonary arterial pressure and the augmentation in venous outflow produced by adrenaline are suppressed or reversed by ergotoxine. 2. Evidence is produced which favours the view that the blood‐vessels responsible for the adrenaline rise in pulmonary pressure differ from those which cause the increase in venous outflow. 3. Histamine in small doses tends to increase and in large doses to diminish the venous outflow. The venous outflow response to histamine is also determined by other experimental conditions; the presence of ether in the lungs and a low venous pressure favour a histamine diminution in outflow. Experiments have been reported which suggest that, by injection of drugs into the pulmonary vascular bed by way of the bronchial arteries, it is possible to confine the site of drug action chiefly or almost exclusively to the pulmonary veins in lungs perfused in the normal direction, and in all probability chiefly or almost exclusively to the pulmonary arteries in lungs perfused in the reverse direction. Using this method, results have been obtained which indicate that adrenaline in small doses constricts both pulmonary arteries and veins, and in large doses probably constricts the pulmonary capillaries. The authors express their thanks to the Government Grants Committee of the Royal Society for a grant to one of them (I. de B. D.) and to the Lewis Cameron Research Fund which defrayed the cost of animals.