Premium
THE MODE OF ACTION OF VERITOL
Author(s) -
Reis August
Publication year - 1940
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1940.sp000818
Subject(s) - vasoconstriction , blood pressure , vasodilation , wish , perfusion , cats , action (physics) , medicine , cardiology , physics , art , literature , quantum mechanics
1. The rise of blood‐pressure produced by veritol is due to two factors: ( a ) vasoconstriction, and ( b ) increased volume output per beat of the heart. Veritol (unlike adrenaline) causes only slight cardiac acceleration. 2. The vasoconstrictor action of veritol can be demonstrated easily on perfused limbs, provided that blood is used for perfusion and the preparation is in good condition. 3. Veritol sometimes causes a vasodilatation of central origin in perfused limbs. 4. As regards the majority of its effects veritol resembles adrenaline, but its effects are of much longer duration. 5. Doses of veritol as large as 20 mg./kg. did not produce any immediate toxic effects on anæsthetised cats. I wish to express my thanks to Professor A. J. Clark for his advice and help throughout this investigation. I also wish to thank Mr. N. E. Condon for his advice in designing the stromuhr.