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PHARMACOLOGICAL ACTIONS OF ACRIDINE DERIVATIVES, WITH ESPECIAL REFERENCE TO THOSE OF ACRIFLAVINE AND ATEBRIN
Publication year - 1939
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1939.sp000789
Subject(s) - acriflavine , acridine , acridine derivatives , acridine orange , chemistry , biochemistry , stereochemistry , organic chemistry , apoptosis
1. Acriflavine in bacteriostatic concentrations produces no toxic effects on the isolated frog's heart, and indeed prolongs rather than shortens the survival period. 2. Out of seventeen acridine compounds tested on the isolated frog's auricle, only one, a chloro compound, was markedly toxic. 3. The majority of the acridine compounds tested antagonised acetyl choline. Some compounds ( e.g. acriflavine and atebrin) showed this action with frog's tissues and mammalian tissues. Other compounds ( e.g. 2‐amino‐acridine monohydrochloride) only showed this action with frog's tissues. 4. No obvious relation could be shown between chemical structure and pharmacological action.