Premium
HÆMOLYSIS AND THE MOBILISATION OF RED CELLS AFTER THE INTRAVENOUS INJECTION OF 30 PER CENT. NaCl
Author(s) -
Robertson J. Douglas,
Barrett J. F.
Publication year - 1938
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1938.sp000788
Subject(s) - tonicity , cats , saline , hypertonic saline , chemistry , plasma volume , physiological saline , red cell , zoology , endocrinology , medicine , biochemistry , biology
1. Injection of 30 per cent. saline causes hæmolysis in cats and also in man (one observation). This hæmolysis also occurs in vitro and is therefore a direct action. 2. The hæmolysis interferes with the determination of blood volume by the vital red method. A method is described whereby plasma may be freed from hæmoglobin to allow determinations to be carried out by this technique. 3. A further effect of hypertonic salt is a mobilisation of red cells and hæmoglobin. When the animals are eviscerated and the liver excluded from the circulation this effect is virtually abolished.