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MECHANISM OF ŒSTRUS INHIBITION IN THE MOUSE DURING PREGNANCY
Author(s) -
Robson J. M.
Publication year - 1938
Publication title -
quarterly journal of experimental physiology and cognate medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0033-5541
DOI - 10.1113/expphysiol.1938.sp000774
Subject(s) - testosterone propionate , luteal phase , testosterone (patch) , hormone , endocrinology , ovary , pregnancy , medicine , administration (probate law) , biology , physiology , andrology , androgen , genetics , political science , law
1. A method for the quantitative estimation of vaginal smears is described. 2. The vaginal changes following the administration of various doses of cœstradiol to pregnant mice have been quantitatively studied and compared with the vaginal effects produced by the administration of similar doses of œstradiol to spayed mice under the influence of progesterone or testosterone propionate. 3. The results suggest that in the pregnant mouse a concentration of progesterone is present similar to that produced by the daily administration of 1·5 mg. of the luteal hormone. There is evidence that a certain quantity of this hormone is produced outside the ovary. The expenses of this investigation have been defrayed by a grant from the Medical Research Council.