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THE INHIBITION OF WATER‐DIURESIS BY EMOTIONAL STRESS AND BY MUSCULAR EXERCISE
Author(s) -
Rydin H.,
Verney E. B.
Publication year - 1938
Publication title -
quarterly journal of experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0370-2901
DOI - 10.1113/expphysiol.1938.sp000757
Subject(s) - diuresis , emotional stress , renal artery , kidney , blood pressure , medicine , inhibitory postsynaptic potential , psychology , endocrinology , anesthesia
1. The inhibition of water‐diuresis induced in the dog by mild exercise of 4 to 5 minutes' duration begins about 2 minutes after the onset of exercise. 2. Emotional stress produces an inhibition of similar form: reasons are given for the view that the inhibition produced by exercise is due to an emotional accompaniment. 3. The course of the inhibitory response to emotional stress is unaltered by successive operations comprising ( a ) division of the renal nerves; ( b ) removal of the right suprarenal and denervation of the left; ( c ) decentralisation of the whole abdominal sympathetic system with removal of ganglia L2 to SI inclusive. After ( a ) and ( b ) the mean arterial pressure rises during emotional stress; after ( c ) it remains unaffected. 4. When, in the normal dog, the renal artery is compressed during water‐diuresis for a period of 2 to 6 minutes, the course of the inhibition shows close temporal accord with that of the compression (confirming Samaan [1936]). 5. The experiments recorded support the view that the inhibition of water‐diuresis by emotional stress is due to some agent humorally conducted to the kidney, and that this agent is not adrenaline. They accord with the view that local hæmodynamic events are not essential accompaniments of the inhibitory action of this substance on the kidney. 6. The course of the inhibitory response to emotional stress can be closely matched by an intravenous injection of post‐pituitary extract. The post‐pituitary equivalent of this stress in terms of the standard powder is of the order of 1 µg. 7. After section of the splanchnic nerves, or after decentralisation of the whole abdominal sympathetic system, a profound and longlasting inhibition of water‐diuresis has been seen to follow arterial hæmorrhage to the extent of about 6 per cent. of the blood‐volume. The inhibition showed no apparent relation with the small and transient fall in blood‐pressure which the hæmorrhage also induced. 8. The experimental results are discussed in the light of the theory of the pituitary control of water‐secretion. We are indebted to the Rockefeller Foundation for defraying part of the expenses of this work.