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STUDIES ON HYPERTROPHY, REGENERATION, AND RETARDATION OF OVARIAN WEIGHTS IN GROWING RATS AFTER ŒSTRONE INJECTIONS
Author(s) -
Emery Frederick E.
Publication year - 1937
Publication title -
quarterly journal of experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0370-2901
DOI - 10.1113/expphysiol.1937.sp000732
Subject(s) - ovary , estrous cycle , endocrinology , medicine , uterus , muscle hypertrophy , compensatory hypertrophy , biology , pituitary gland , spleen , regeneration (biology) , kidney , thyroid , body weight , hormone , microbiology and biotechnology
1. The effects of œstrone on the estrous cycle, ovaries, hypophysis, and several other organs have been studied in semi‐ovariectomised rats, in rats with one‐half of each ovary removed, and in rats with entire ovaries. 2. Œstrone in 1 to 20 rat units daily for six weeks had little, if any, effect on the secretion of the hypophysis as shown by (1) normal hypertrophy of the remaining ovary, (2) normal regeneration of ovarian fragments, and (3) insignificant reduction in the weight of the entire ovaries. 3. The length of the estrous cycles was practically unaffected, but the percentage of time in estrus was somewhat longer in the œstrone injected groups. This latter effect may not be specific, as shown by similar results in the saline injected controls. 4. The spleen, liver, lungs, and thymus were slightly increased in weight. The adrenals, pituitary, uterus, thyroid, heart, kidneys, intestines, and brain were unchanged in weight by œstrone. 5. A discussion indicating that ovarian hypertrophy and regeneration may not be entirely controlled by the action of œstrone on the pituitary gland is presented for consideration.