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THE PHYSIOLOGY OF PREGNANCY IN THE RAT. THE COMBINED ACTION OF MALE AND FEMALE HORMONES (TESTOSTERONE PROPIONATE AND ŒSTRONE)
Author(s) -
Hain A. M.
Publication year - 1937
Publication title -
quarterly journal of experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0370-2901
DOI - 10.1113/expphysiol.1937.sp000721
Subject(s) - testosterone propionate , medicine , testosterone (patch) , endocrinology , hormone , pregnancy , anterior pituitary , gestation , biology , androgen , genetics
1. An antagonistic action was observed in the ovariectomised rat between œstrone and testosterone propionate (male hormone), the latter annulling the œstrogenic effect of the former. 2. In the pregnant rat, male hormone did not overcome the interruptive action of œstrone even in very large amounts. 3. Such amounts were themselves interruptive in effect when administered alone at the same stage of gestation. 4. These amounts had no œstrogenic effect on ovariectomised rats. 5. It is concluded that the interruptive effect of male hormone on pregnancy is probably specific, and may be by way of the anterior pituitary or other ductless gland. The expenses of this investigation were defrayed by grants from the Carnegie Trust and the Medical Research Council.