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SYNERGY OF ADRENALINE AND ACETYLCHOLINE ON THE PULMONARY BLOOD‐VESSELS IN THE RABBIT
Author(s) -
Ettinger G. Harold,
Hall G. Edward
Publication year - 1935
Publication title -
quarterly journal of experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0370-2901
DOI - 10.1113/expphysiol.1935.sp000685
Subject(s) - acetylcholine , constriction , histamine , pulmonary artery , medicine , blood vessel , rabbit (cipher) , endocrinology , anesthesia , anatomy , chemistry , mathematics , statistics
1. Acetylcholine is capable of producing powerful constriction of the pulmonary blood‐vessels in the rabbit. 2. The constriction depends upon an initial tone of the blood‐vessels. 3. In the perfused blood‐vessels repeated injections of acetylcholine produce a condition in which the muscle fails to respond, probably because acetylcholine promotes dilatation following the constriction. The sensitivity, i.e. the muscle tone, may be restored by adrenaline, barium or histamine. 4. In the living animal the tone is probably mediated by the sympathetic nerves or by adrenaline. 5. The hypothesis is offered that major changes in the calibre of the pulmonary artery and arterioles of the rabbit are brought about through parasympathetic activity.