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THE EFFECT OF ADRENALINE AND OF INCREASED WORK ON THE CARBOHYDRATE METABOLISM OF THE MAMMALIAN HEART
Author(s) -
Bogue J. Yule,
Evans C. Lovatt,
Grande F.,
Hsu F. Y.
Publication year - 1935
Publication title -
quarterly journal of experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0370-2901
DOI - 10.1113/expphysiol.1935.sp000681
Subject(s) - glycogen , blood lactate , blood sugar , carbohydrate metabolism , energy expenditure , medicine , energy metabolism , endocrinology , skeletal muscle , sugar , work (physics) , carbohydrate , biology , biochemistry , heart rate , blood pressure , mechanical engineering , engineering , diabetes mellitus
1. Increase in the energy expenditure of the dog's heart by the addition of adrenaline to the circulating blood increases the utilization of both sugar and lactate. 2. The same holds true for increase in energy expenditure by raising the mechanical work done. 3. Cardiac muscle appears to differ fundamentally from skeletal muscle in the ease with which it uses lactate. 4. It is suggested that the lactate is burned by the tissue to yield energy, whereas the sugar is used to replace glycogen usage. When the blood sugar and lactate have fallen to a low level the heart glycogen is drawn upon, especially if the energy expenditure has been high. Part of the costs of this research have been defrayed by a grant from the Royal Veterinary College to one of us (J. Y. B.).