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INFLUENCE OF DEPRESSANTS ON RATE OF ASPHYXIATION OF FROG'S VENTRICLE
Author(s) -
Clark A. J.
Publication year - 1935
Publication title -
quarterly journal of experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0370-2901
DOI - 10.1113/expphysiol.1935.sp000675
Subject(s) - ventricle , metabolism , medicine , chemistry
1. The rate of asphyxial exhaustion in the empty and contracting ventricle is about two‐thirds that of the full and contracting ventricle and twice that of the ventricle when arrested and either filled or empty. The passage of a wave of excitation over the ventricle therefore causes a considerable increase in metabolism although no work is performed (correction of conclusions of Clark and White [1928 and 1930]). 2. The resting metabolism of the ventricle has a Q/10 of about 2 between 5° C. and 25° C. (confirming Weizsäcker, [1912]). 3. The metabolism added by contraction (total metabolism‐resting metabolism) is lower at 5° C. than at 10° C., but the effect on this value of increasing the temperature above 10° C. is uncertain. 4. Acetylcholine reduces the metabolism of the arrested ventricle to about one‐half of its normal value. The expenses of this research were defrayed by a grant from the Moray Research Fund, for which the author desires to express his thanks.