Premium
THE EFFECT OF IODOACETATE ON POST‐MORTEM GLYCO‐GENOLYSIS IN LIVER
Author(s) -
Noltie H. R.
Publication year - 1935
Publication title -
quarterly journal of experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0370-2901
DOI - 10.1113/expphysiol.1935.sp000658
Subject(s) - glycogenolysis , lactic acid , chemistry , liver metabolism , biochemistry , medicine , biology , glycogen , bacteria , genetics
1. lodoacetate did not prevent glycogenolysis in rabbit liver slices, incubated in nitrogen at 38°, either when injected prior to decapitation or when in the suspending medium. 2. lodoacetate caused the lactic acid concentration to become stationary, but required one to two hours to achieve complete inhibition. 3. lodoacetate did not prevent accumulation of sugar, although it appears to have exerted a braking effect on its production. The author wishes to record his thanks to Professor J. J. R. Macleod for his interest and advice; and to the Medical Research Council for assistance from their grant to Professor Macleod and Dr J. M. Peterson.