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THE DEVELOPMENT OF THE POLYMORPHONUCLEAR LEUCOCYTE IN THE BLOOD STREAM
Author(s) -
Climenko David R.,
Ponder Eric
Publication year - 1934
Publication title -
quarterly journal of experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0370-2901
DOI - 10.1113/expphysiol.1934.sp000649
Subject(s) - blood stream , in vitro , immunology , bone marrow , stimulation , class (philosophy) , chemistry , biology , medicine , philosophy , endocrinology , biochemistry , epistemology
1. The polymorphonuclear leucocytes kept under in vitro conditions do not show development from one class of the polynuclear count to another, as might be expected on theoretical grounds, nor can such development be observed under ordinary circumstances in ligated veins. The reason for this is that the slow forward development is masked by the appearance of cytolysed and degenerate forms, and also that the number of cells which are affected by the developmental process in a limited time is too few in normal blood. 2. If the number of young forms in the blood is increased by a stimulation of the bone marrow, development from Class I. to Class II. can be demonstrated in isolated veins. A number of the in vitro experiments were carried out by Dr. George Saslow and Dr. Malvina Schweizer, whom we have to thank for kindly placing their results at our disposal.