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INVESTIGATIONS ON THE PHARMACOLOGY OF EVIPAN SODIUM
Author(s) -
Kennedy Walter P.,
Narayana Basudeva
Publication year - 1934
Publication title -
quarterly journal of experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0370-2901
DOI - 10.1113/expphysiol.1934.sp000626
Subject(s) - sodium , depressant , pharmacology , chemistry , medicine , organic chemistry
(1) The depressant action of evipan sodium on the frog heart is very rapidly removed by washing, and is antagonised by adrenalin. Complete recovery can be obtained in a few minutes. (2) No significant effect is produced by evipan sodium on the blood‐sugar of rabbits or guinea‐pigs. (3) Respiration is markedly slowed and temperature reduced by this anæsthetic. (4) The detoxication of evipan sodium in mammals is very rapid. The investigation was carried out under a grant from the Carnegie Trust, and Bayer Products kindly supplied the evipan sodium used.