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THE MODE OF ACTION OF VASODILATOR AND VASO‐CONSTRICTOR NERVES
Author(s) -
Bain W. A.
Publication year - 1933
Publication title -
quarterly journal of experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0370-2901
DOI - 10.1113/expphysiol.1933.sp000611
Subject(s) - vasomotor , vasodilation , stimulation , perfusion , medicine , peripheral , cats , chemistry , endocrinology , anatomy
1. Experiments on the perfused tongue of the dog, which demonstrate directly that vasomotor nerves produce their effects by the peripheral liberation of chemical substances, are described. 2. It is shown that stimulation of the vasodilator nerves liberates a substance which can be transmitted humorally to an isolated strip of rabbit intestine and cause augmentation of the tone and/or contractions of this. 3. It is shown similarly that stimulation of the sympathetic supply to the blood‐vessels liberates a substance which diminishes the tone and/or contractions of an isolated strip of intestine. 4. An experiment is described in which the effects of spontaneous changes in vasomotor activity (Traube‐Hering effect) were humorally transmitted to the test tissue. 5. The effects described are only obtained when the perfusion fluid (Dale's solution) is uncontaminated with blood. 6. It is pointed out that the humoral transmission of the substances responsible for these effects is the method of demonstrating the existence of the neuromimetic substances, and that under normal circumstances such transmission is probably of little significance.