Premium
THE EFFECT OF ORAL ADMINISTRATION OF CREATININE ON BLOOD AND URINE
Author(s) -
Cameron J. D. S.
Publication year - 1933
Publication title -
quarterly journal of experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0370-2901
DOI - 10.1113/expphysiol.1933.sp000608
Subject(s) - creatinine , urine , renal function , medicine , urinary system , ingestion , oral administration , urology , endocrinology
1. The constancy of blood and urinary creatinine amounts is verified during periods of ( a ) protein and ( b ) non‐protein diet. 2. The effect of ingestion of 1, 3, 5, and 7 grm. of creatinine upon blood and urine contents is recorded. 3. Administration of 1 grm. creatinine to a series of normal individuals shows that wide variations of response are obtained. 4. Similar administration to subjects of renal impairment gives no information which cannot be obtained from estimation of “fasting” blood creatinine concentration. 5. These findings suggest the unsuitability of creatinine administration as a test for renal function. 6. It is concluded that raised blood creatinine concentration alone does not cause “uræmic” symptoms. This work was carried on with the aid of a grant from the Earl of Moray Fund of the University of Edinburgh.