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ADRENALINE AND VENTRICULAR FIBRILLATION IN THE DECAPITATED CAT
Author(s) -
Schlapp Walter
Publication year - 1933
Publication title -
quarterly journal of experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0370-2901
DOI - 10.1113/expphysiol.1933.sp000605
Subject(s) - ventricular fibrillation , medicine , sodium bicarbonate , blood pressure , cardiology , anesthesia , fibrillation , atrial fibrillation , chemistry
1. The pressor response of the decapitated cat to the intravenous injection of adrenaline varies with the time after decapitation; an interruption appears on the ascending portion of the blood‐pressure tracing, which is due to cardiac irregularities of an extra‐systolic type, and may lead to ventricular fibrillation. 2. After the intravenous administration of sodium bicarbonate, intravenous injection of adrenaline will produce ventricular fibrillation, provided that a sufficient time interval has elapsed since the decapitation. Immediately after decapitation the phenomenon is not seen. 3. No direct relationship between the degree of alkalinity of the blood consequent on over‐ventilation, and the onset of ventricular fibrillation from the injection of adrenaline has been found. Fibrillation has not been observed in animals in which the reaction of the blood was kept normal by the administration of CO 2 . I wish to thank Dr F. W. Lamb for his encouragement and advice.