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THE ACTION OF PITUITARY EXTRACTS ON THE KIDNEY
Author(s) -
MacDonald A. D.
Publication year - 1933
Publication title -
quarterly journal of experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0370-2901
DOI - 10.1113/expphysiol.1933.sp000604
Subject(s) - diuresis , atropine , endocrinology , medicine , kidney , posterior pituitary , blood pressure , dilator , morphine , pituitary gland , chemistry , hormone
1. The action of posterior lobe pituitary extracts on the renal vessels is not dilator, as is usually stated. In the pig, marked contraction has been found. In the cat, rabbit, sheep, and cow the plain muscle of the arteries is scarcely affected by pituitary extracts, though sensitive to other drugs. 2. The full course of the action of the extracts on the volume of the kidney in situ in the cat, whether anæsthetised or spinal, and, under favourable circumstances, in the dog, consists of a brief initial diminution in volume, a short increase in volume, and a prolonged secondary diminution. The increase in volume is believed to be passive; it can be produced also by adrenaline. 3. It is shown that in unanæsthetised man and in the lightly anæsthetised dog even intravenous injection may not raise the blood‐pressure nor increase excretion. Diuresis can be produced in the decerebrate or spinal cat, and is thus less dependent on the presence of an anæsthetic than on the action taking place in an animal in which the blood‐pressure can be significantly raised, as in the cat or in the dog after ether or morphine and atropine. 4. It is concluded from experiments on the cat, dog, rabbit, and man that the diuretic action is associated with rise of blood‐pressure, and is always followed by anti‐diuresis.