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STUDIES ON THE FUNCTION OF THE INTESTINAL MUSCULATURE.—III. ARE THE INTESTINAL MOVEMENTS NEUROGENIC OR MYOGENIC?
Author(s) -
Krishnan B. T.
Publication year - 1933
Publication title -
quarterly journal of experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0370-2901
DOI - 10.1113/expphysiol.1933.sp000583
Subject(s) - peristalsis , rhythm , anatomy , plexus , ileum , interstitial cell of cajal , myenteric plexus , neuroscience , smooth muscle , biology , chemistry , medicine , endocrinology , immunohistochemistry
1. The normal peristaltic movement as well as the peristaltic rlus seen at the time of death is dependent upon local nerve‐plexuses. 2. Experimental evidence is given to show that the rhythmic contractions become slow and irregular, or cease altogether, whenever a neurotropic poison is injected into an animal, or painted on the intact bowel, or added to a bath conitaining excised segments of the bowel. 3. It is concluded that, although the intestinal muscle may, with suitable nourishment, show automatic rhythm, it is to a large extent dependent upon the enteric nerve cells and fibres for its normal rhythmic activity. The functioning of the Auerbach plexus in rhythmic contractions is necessary for bringing about a reciprocal inhibition in the activity of the two muscle‐layers of the intestinal wall. 4. Pendular movements, which are longitudinal muscle phenomena, are also dependent on Auerbach's plexus. I wish to express my thanks to Mr C. K. Prasada Rao and Mr C. Vareed for technical assistance in the experiments.