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THE INHIBITION OF (ESTRUS BY CORPUS LUTEUM EXTRACTS
Author(s) -
Patel J. S.
Publication year - 1930
Publication title -
quarterly journal of experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0370-2901
DOI - 10.1113/expphysiol.1930.sp000502
Subject(s) - corpus luteum , estrous cycle , pregnancy , ovary , endocrinology , medicine , secretion , stimulus (psychology) , andrology , biology , psychology , psychotherapist , genetics
Kythin inhibits œstrus by producing pseudo‐pregnancy conditions in the injected mice. The inhibition of œstrin can be obtained for a long period (40 days in some cases) without causing any permanent injury to the ovaries. Preliminary experiments show that the œstrus is prevented by the inhibition of œstrin‐secretion from the ovary, whose reactivity to the œstrogenic stimulus of the pituitary is reduced (but not removed). The response of the vagina to œstrin is also slightly reduced. There is no “neutralisation” of œstrin by kythin. It is probable that the kythin also acts on the pituitary, inhibiting the secretion of the œstrogenic substance of the pituitary—a condition similar to that found during pregnancy. The writer desires to acknowledge his indebtedness to Professor F. A. E. Crew and to Dr B. P. Wiesner for their kind criticism and help.