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THE ACTION OF DRUGS UPON THE MOVEMENTS OF THE STOMACH
Author(s) -
M'Crea E. D.,
Macdonald A. D.
Publication year - 1928
Publication title -
quarterly journal of experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0370-2901
DOI - 10.1113/expphysiol.1928.sp000460
Subject(s) - physostigmine , pilocarpine , stomach , atropine , stimulation , strychnine , inhibitory postsynaptic potential , medicine , histamine , chemistry , anesthesia , endocrinology , pharmacology , cholinergic , epilepsy , psychiatry
1. Adrenaline may produce both inhibitory or augmentor effects on the stomach of the cat and dog, but its action is chiefly inhibitory. It cannot be said to duplicate the effects of faradic stimulation of the splanchnic nerves. 2. Pilocarpine, physostigmine, and acetyl‐choline, like the vagus, can be both augmentor and depressor to the stomach, according to its condition of tonus. Pilocarpine and physostigmine often cause irregular after‐contractions of considerable duration. 3. Atropine relaxes and paralyses the stomach‐musculature and abolishes all response to nervous stimulation or to other drugs. 4. The effects of ephedrine, ergotamine, strychnine, histamine, and pituitary extracts are briefly described. 5. An explanation is advanced of the varying results of nerve‐stimulation and of drugs.