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STUDIES ON THE PITUITARY.—VI. LOCALISATION AND PHYLETIC DISTRIBUTION OF ACTIVE MATERIALS
Author(s) -
Hogben Lancelot T.,
de Beer Gavin R.
Publication year - 1925
Publication title -
quarterly journal of experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0370-2901
DOI - 10.1113/expphysiol.1925.sp000350
Subject(s) - phyletic gradualism , pituitary gland , endocrinology , cerebrospinal fluid , medicine , biology , skate , anatomy , neuroscience , biochemistry , hormone , fishery , phylogenetics , gene
1. The oxytocic and avine depressor responses are given by extracts of the pituitary of mammals, birds, reptiles, amphibians, bony and cartilaginous fishes ; but the activity of extracts of the elasmobranch pituitary is in both respects so small compared with that of extracts of the teleost that no special significance can be attached to the failure of attempts to obtain a rise in blood‐pressure from extracts of the skate's gland. 2. Comparison of the pressor and oxytocic activity of the same extracts of three separate samples of fresh bovine glands with Dale's uterine technique and the method of pressor standardisation outlined in a previous contribution to this series yielded results consistent with Herring's conclusion that, as compared with extracts of the pars nervosa, extracts of the pars inter media have a higher oxytocic than pressor activity. 3. It is incorrect to state that there is no nervous tissue in the elasmobranch pituitary, though the nervous element is small in amount. 4. In the present state of knowledge it is perhaps premature to conclude either that the pressor and oxytocic material originate in the cells of the pars inter media or that they pass directly into the cerebrospinal fluid via the pars nervosa.