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THE ACTION OF CERTAIN GLAND EXTRACTS AND DRUGS UPON THE UTERUS OF THE RAT
Author(s) -
Itagaki M.
Publication year - 1917
Publication title -
quarterly journal of experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0370-2901
DOI - 10.1113/expphysiol.1917.sp000235
Subject(s) - uterus , endocrinology , medicine , contraction (grammar) , atropine , pilocarpine , rhythm , chemistry , tone (literature) , muscle tone , biology , neuroscience , art , literature , epilepsy
The results of these experiments upon the rat‐uterus may be briefly stated thus:— 1. Extract of posterior lobe of pituitary always produces an increase of tone. 2. Solutions of adrenalin inhibit the rhythmic contractions (with or without diminution of tone). 3. Extract of thyroid occasionally produces an increase of tone, but generally has no effect. 4. Extracts of orchitic substance, of uterus, and of brain have no appreciable effect. 5. The action of nicotine is variable. Weak solutions produce an increase of tone. Stronger solutions cause first inhibition, then increased contraction. Still stronger solutions produce inhibition alone. 6. The action of pilocarpine is inconstant, but usually an increase of tone is produced. 7. Weak solutions of atropine produce increase of the rhythmic contractions; stronger solutions, a slight diminution; but even with a very strong solution there is no absolute arrest of the contractions. 8. Barium chloride in all strengths which produce any effect causes increased tone and stimulates the rhythmic contractions.