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THE PARATHYROIDS:—TETANIA PARATHYREOPRIVA: ITS NATURE, CAUSE, AND RELATIONS TO IDIOPATHIC TETANY. PART VII.: A COMPARISON OF THE INFLUENCE ON THE PROTEIN METABOLISM OF PARATHYROIDECTOMY AND OF THE ADMINISTRATION OF GUANIDIN
Author(s) -
Burns David
Publication year - 1917
Publication title -
quarterly journal of experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0370-2901
DOI - 10.1113/expphysiol.1917.sp000230
Subject(s) - tetany , excretion , urea , endocrinology , medicine , urine , chemistry , parathyroidectomy , metabolism , nitrogen mustard , ammonia , hydrochloride , biochemistry , calcium , parathyroid hormone , chemotherapy , cyclophosphamide
After the administration of guanidin hydrochloride— 1. The excretion of nitrogen was increased immediately and out of all proportion to the dose. 2. The ratio of urea nitrogen to total nitrogen was decreased. 3. The proportion of the total urinary nitrogen excreted in the form of ammonia showed either a slight decrease in feeding animals and generally a slight increase in animals which refused food and in one animal where tremors appeared. 4. The excretion of creatinin was only slightly, if at all, increased. 5. The percentage of undetermined nitrogen rose markedly immediately after injection of guanidin.