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THE ACTION OF PROTOVERATRINE AND ACONITINE ON THE NEURO‐MUSCULAR APPARATUS OF THE FROG
Author(s) -
MacNaughton Marjory
Publication year - 1913
Publication title -
quarterly journal of experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0370-2901
DOI - 10.1113/expphysiol.1913.sp000156
Subject(s) - aconitine , medicine , yohimbine , stimulation , anatomy , anesthesia , pharmacology , receptor , antagonist
1. The action of protoveratrine upon nerve fibres, when tested by the method of rapid serial stimulation, the muscle response being used as an index of the processes occurring in the nerve, closely resembles that of yohimbine. A protoveratrinised nerve shows “fatigue” upon activity and recovery after rest. A rest of several minutes is sometimes necessary before the conductivity of the nerve is restored, There is no “Wedensky effect.” 2. There are, however, certain differences between protoveratrine and yohimbine. Protoveratrine produces a more lasting “fatigue” in nerve fibres than does yohimbine. Again, the snap reflex in the frog produced by yohimbine is not produced by protoveratrine. 3. The action of aconitine upon nerve fibres is similar to that of protoveratrine. 4. Protoveratrine has a special action upon the myo‐neural junction. After this has been exposed to the action of protoveratrine, stimulation through the nerve causes a rapid and permanent “fatigue.” 5. Aconitine is without this action.