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THE ANTAGONISM BETWEEN ADRENINE AND CHLOROFORM, CHLORAL, ETC., ON THE HEART; AND THE INDUCTION OF RHYTHMIC CONTRACTIONS IN THE QUIESCENT HEART BY ADRENINE
Author(s) -
Gunn James A.
Publication year - 1913
Publication title -
quarterly journal of experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0370-2901
DOI - 10.1113/expphysiol.1913.sp000152
Subject(s) - antagonism , medicine , heart rhythm , rhythm , chloral hydrate , contraction (grammar) , diastole , cardiac cycle , beat (acoustics) , heart beat , cardiology , chemistry , endocrinology , anesthesia , blood pressure , receptor , physics , acoustics
(1) In regard to the perfused isolated heart of the rabbit or cat, adrenine can antagonise a concentration of chloroform which markedly enfeebles the heart's contractions, but not such a concentration as completely arrests the heart. (2) Adrenine exerts a more complete antagonism to chloral, being able to revive rhythmic contractions in a heart arrested in diastole by chloral. It cannot antagonise a (greater) strength of solution of chloral which is sufficient to arrest the heart in systole. (3) Adrenine has an action on the heart antagonistic to that of many other substances which slow the heart or weaken systolic contraction. (4) The rhythmic contractions aroused in a quiescent heart by adrenine are regarded as independent of intrinsic motor ganglia. (5) The cardiac sympathetic nerve is an originator‐accelerator‐augmentor nerve of the heart's contractions.