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AGE AS A FACTOR IN THE EFFECTS WHICH FOLLOW THYROIDECTOMY AND THYROPARATHYROIDECTOMY IN THE SHEEP
Author(s) -
Simpson Sutherland
Publication year - 1913
Publication title -
quarterly journal of experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0370-2901
DOI - 10.1113/expphysiol.1913.sp000136
Subject(s) - tetany , parathyroidectomy , medicine , thyroidectomy , thyroid , surgery , pediatrics , endocrinology , parathyroid hormone , calcium
1. Removal of the thyroid with the contained internal parathyroids in thirteen adult sheep and sixteen lambs from seven to eight months old, led to practically no ill effects. 2. As the result of a similar operation, three lambs about two months old became typical cretins. 3. The complete operation (thyro‐parathyroidectomy) in four adult sheep was followed by no symptoms during the time (three to four months) they were under observation. 4. The same operation (thyro‐parathyroidectomy) in four young lambs (five to seven weeks) resulted early in acute and fatal tetany. 5. Removal of the two external parathyroids from the three cretins when about one year old was followed by only slight symptoms. With regard to the effects both of thyroidectomy and of parathyroidectomy in the sheep, age is a very important factor.