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THE ACTION OF DRUGS UPON THE CEREBRAL VESSELS
Author(s) -
Dixon W. E.,
Halliburton W. D.
Publication year - 1910
Publication title -
quarterly journal of experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0370-2901
DOI - 10.1113/expphysiol.1910.sp000075
Subject(s) - dilator , constriction , pilocarpine , medicine , anesthesia , epilepsy , psychiatry
The cerebral blood‐vessels respond towards drugs in a manner similar to the pulmonary and coronary vessels. Adrenaline, pilocarpine, and muscarine, drugs well recognised as acting upon nerve‐endings, cause some dilatation, though they always produce marked constriction of systemic vessels. It is probable that the dilator action is confined to the larger blood‐vessels, and it is suggested that this effect is nervous in origin. Barium, lead, veratrine, and pituitary extract cause some constriction, the inference being that these drugs act directly upon muscle. The constriction with pituitary is slight and transient, and is followed by decided dilatation.