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EFFECTS OF HYPOPHYSEAL TRANSPLANTATION FOLLOWING TOTAL HYPOPHYSECTOMY IN THE CANINE
Author(s) -
Crowe S. J.,
Cushing Harvey,
Homans John
Publication year - 1909
Publication title -
quarterly journal of experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0370-2901
DOI - 10.1113/expphysiol.1909.sp000049
Subject(s) - transplantation , polyuria , hypophysectomy , lobe , cortex (anatomy) , necrosis , medicine , anatomy , biology , endocrinology , neuroscience , hormone , diabetes mellitus
The experimental transplantation of fragments of ductless glands has in the past not met with striking success, possibly due to the fact that the principle emphasised by W. S. Halsted, that an existing “physiological deficit” is one of the essentials to a successful “take,” has been disregarded. Our experiences conform with those of others in showing that the transplanted glandular tissue—in this case the hypopyhsis—is prone to undergo necrosis and in the course of time to become replaced by fibrous tissue. It is nevertheless apparent, particularly in the cases of immediate auto‐transplantation of the gland into the cortex cerebri, that the inevitable early consequence of a total hypophysectomy (cachexia hypophyseopriva) can be postponed; further, in the case of animals in whom a minute fragment only of anterior lobe remains, the transplant seems to have been the means of tiding them over a period in which, according to our previous experiences, death would certainly have occurred. These fragments we have subsequently found to show evidences of the condition which we regard as hypertrophy. The transplants themselves, both anterior and posterior lobe, show histological evidences of retained activity for periods of at least a month. It has been observed that marked polyuria follows the cortical transplantation of the entire gland; that it disappears after extirpation of the transplant; that it does not follow transplantation of the posterior lobe alone; and, further, that it does not occur in control animals with heterotransplants.