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ON THE MECHANISM OF CYTOLYSIS IN PARAMECIUM
Author(s) -
Wulzen Rosalind
Publication year - 1909
Publication title -
quarterly journal of experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0370-2901
DOI - 10.1113/expphysiol.1909.sp000043
Subject(s) - cytolysis , protoplasm , intracellular , paramecium , membrane , vesicle , lysis , vacuole , biophysics , microbiology and biotechnology , osmotic pressure , biology , cytoplasm , chemistry , biochemistry , in vitro , cytotoxicity
1. The same agents which cause cytolysis in the sea‐urchin egg and the red blood‐corpuscle produce also cytolysis in Paramecium. 2. The formation of a membrane is an essential step in this cytolysis The membrane is raised in vesicles by an increase in intracellular osmotic pressure. This pressure is due to the production of some soluble colloid by the action of the cytolytic agent upon the protoplasm. 3. The intracellular change indicated by vesicle‐formation renders the cell‐wall soluble in the cytolytic agent, and the cell‐contents are thus extruded. 4. In complete cytolysis the protoplasm is entirely dissolved. 5. The membranes about both contractile vacuoles and nucleus are probably membranes of precipitation. 6. These membranes resist lipoid solvents to such an extent that they probably contain but little lipoid. To Professor Loeb's kind suggestions is owing anything in this paper which may be of value.