The Role of Mitochondria in Cytoplasmic Ca 2+  Cycling | Zendy

Ganitkevich V. Y. | Zendy

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The Role of Mitochondria in Cytoplasmic Ca 2+ Cycling

Author(s) -

Ganitkevich V. Y.

Publication year - 2003

Publication title -

experimental physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.925

H-Index - 101

eISSN - 1469-445X

pISSN - 0958-0670

DOI - 10.1113/eph8802504

Subject(s) - cytoplasm , mitochondrion , endoplasmic reticulum , organelle , microbiology and biotechnology , calsequestrin , calcium , chemistry , cytosol , receptor , biology , biochemistry , biophysics , ryanodine receptor , organic chemistry , enzyme

It has been known for a long time that isolated mitochondria are able to accumulate large amounts of calcium ions. Before the discovery that endoplasmic reticulum (ER) was the main Ca 2+ ‐storing cellular organelle, mitochondria were thought to play a major role in cytoplasmic Ca 2+ homeostasis (Carafoli, 2002). After IP 3 was discovered and it was shown that IP 3 receptors were localized in ER membrane and that Ca 2+ ‐binding proteins such as calsequestrin could store large amounts of Ca 2+ in the ER, the role of mitochondria in the regulation of cytoplasmic Ca 2+ was questioned. However, in recent years, mostly due to the development of new methods, there has been increasing evidence that mitochondria could be an important cytoplasmic Ca 2+ sink, especially under conditions of a high cellular Ca 2+ load.

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