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The Role of Mitochondria in Cytoplasmic Ca 2+ Cycling
Author(s) -
Ganitkevich V. Y.
Publication year - 2003
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1113/eph8802504
Subject(s) - cytoplasm , mitochondrion , endoplasmic reticulum , organelle , microbiology and biotechnology , calsequestrin , calcium , chemistry , cytosol , receptor , biology , biochemistry , biophysics , ryanodine receptor , organic chemistry , enzyme
It has been known for a long time that isolated mitochondria are able to accumulate large amounts of calcium ions. Before the discovery that endoplasmic reticulum (ER) was the main Ca 2+ ‐storing cellular organelle, mitochondria were thought to play a major role in cytoplasmic Ca 2+ homeostasis (Carafoli, 2002). After IP 3 was discovered and it was shown that IP 3 receptors were localized in ER membrane and that Ca 2+ ‐binding proteins such as calsequestrin could store large amounts of Ca 2+ in the ER, the role of mitochondria in the regulation of cytoplasmic Ca 2+ was questioned. However, in recent years, mostly due to the development of new methods, there has been increasing evidence that mitochondria could be an important cytoplasmic Ca 2+ sink, especially under conditions of a high cellular Ca 2+ load.