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A Simple Method for Generating a Blood Pressure‐Unit Activity Relationship for Central Cardiovascular Neurons in the Rat
Author(s) -
Cividjian A.,
Rentero N.,
McAllen R.,
Quintin L.
Publication year - 2002
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1113/eph8702410
Subject(s) - medulla oblongata , blood pressure , balloon catheter , aorta , aortic pressure , cardiology , medicine , balloon , cardiac function curve , medulla , anesthesia , neuroscience , central nervous system , biology , heart failure
One way to identify central cardiovascular neurons is to consider their barosensitivity, for example by plotting changes in their single unit activity as a function of evoked changes in blood pressure. To simplify the genesis of such pressure‐activity relationships, a coronary angioplasty catheter was threaded into the aorta of anaesthetized rats and the balloon inflated to raise the blood pressure mechanically. Here, such a procedure is exemplified for cardiac vagal motoneurons in the medulla oblongata in eight rats. This simplification bypasses potentially problematic surgery and minimizes deterioration of the animal.