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The Postnatal Development of Tail‐Flick Latencies to Acute and Repeated Stimulation in the Rat
Author(s) -
Hassmannová Jarmila,
Rokyta Richard
Publication year - 2002
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1113/eph8702215
Subject(s) - stimulation , nociception , weaning , period (music) , tail flick test , latency (audio) , endocrinology , medicine , physical stimulation , anesthesia , receptor , physics , engineering , acoustics , electrical engineering
The development of the reaction to thermal nociceptive stimulation was studied in neonatal rats of two strains (albino Wistar and pigmented Long‐Evans). Using the tail‐flick method in neonates of both strains the effects of daily repeated thermal stimulation (sensitisation) were compared to those of acute stimulation applied on 1 day only. During the whole postnatal development period studied (3‐28 days) the pigmented rat pups were more sensitive to a repeated thermal nociceptive stimulation than the albinos. The latency of the response did not change linearly during the developmental time studied, but had a pronounced peak (decreased sensitivity) in the period of eye‐lid opening. In the pigmented animals the peak appeared 1 day earlier than in the albinos. At the time of the weaning period the latencies of the response were again shorter.